The EGG (Early Growth Genetics) Consortium represents a collaborative effort to combine data from multiple genome-wide association studies (GWAS) in order to identify additional human genome loci that have an impact on a variety of traits related to early growth.
The consortium has initially studied child birth weight (Freathy et al. Nature Genetics 2010, Horikoshi et al. Nature Genetics 2013, Horikoshi et al. Nature 2016), as well as performing meta-analyses of more detailed measures of birth head circumference (Taal et al. Nature Genetics 2012, Ikram et al. Nature Genetics 2012), birth length (van der Valk et al. Human Molecular Genetics 2014), childhood obesity (Bradfield et al. Nature Genetics 2012, Bradfield et al. Human Molecular Genetics 2019), pubertal growth (Cousminer et al. Hum Molec Genet. 2013), Tanner stage (Cousminer et al. Hum Molec Genet. 2014), childhood BMI (Felix et al. Hum Molec Genet. 2015), gestational weight gain (Warrington et al. Int J Obes. 2017), gestational duration (Liu et al. Nature Comms. 2019), and offspring birth weight (Beaumont et al. Human Molecular Genetics 2018). Through these efforts, many loci influencing these traits have been identified, a subset of which also influence adult traits and diseases.
Datasets Available For Download
- Birth Length Summary Data
- Birthweight Summary Data (2013)
- Birthweight Summary Data (2016)
- Birthweight Summary Data (2019)
- Childhood Obesity Summary Data (2012)
- Childhood Obesity Summary Data (2019)
- Head Circumference Summary Data
- Pubertal Growth Summary Data
- Tanner Stage Summary Data
- Childhood BMI Summary Data
- Gestational Duration Data (2019)
- Gestational Weight Gain Data
- Maternal GWAS of Offspring Birth Weight Summary Data