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Childhood body mass index (BMI) meta-analysis summary data

The file "EGG_BMI_HapMap_DISCOVERY.txt.gz" includes the rs-number (RSID), chromosome (CHR), position (POS), effect allele (EA), non-effect allele (NEA), beta (BETA), standard error (SE), p-value (P) and total sample size (N) for almost 2.5 million single nucleotide polymorphisms (SNPs), imputed to the HapMap project reference set.

The phenotype analyzed was BMI at the latest time point (oldest age) between 2 and 10 years, transformed into sex- and age-adjusted standard deviation scores (SDS-BMI). Syndromic cases of obesity and children of non-European ethnic origin were excluded. In case of multiple births (twins, triplets), only one child was included, either randomly or based on genotyping or imputation quality.

Linear regression models assuming an additive genetic model were run in each study, to assess the association of each SNP with SDS-BMI, adjusting for principal components if this was deemed needed in the individual studies. As SDS-BMI is age- and sex-specific, no further adjustments were made. The dataset includes the results of the inverse-variance weighted fixed-effects meta-analysis of the 20 studies included in the discovery phase (total N = 35,668).

Acknowledging The Data

When using data from the downloadable meta-analyses results please acknowledge the source of the data as follows:

Data on the childhood BMI trait has been contributed by the EGG Consortium and has been downloaded from www.egg-consortium.org.

In addition to the above acknowledgement, please cite the paper below:

Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.

Felix JF, Bradfield JP, Monnereau C, van der Valk RJ, Stergiakouli E, Chesi A, Gaillard R, Feenstra B, Thiering E, Kreiner-Møller E, Mahajan A, Pitkänen N, Joro R, Cavadino A, Huikari V, Franks S, Groen-Blokhuis MM, Cousminer DL, Marsh JA, Lehtimäki T, Curtin JA, Vioque J, Ahluwalia TS, Myhre R, Price TS, Vilor-Tejedor N, Yengo L, Grarup N, Ntalla I, Ang W, Atalay M, Bisgaard H, Blakemore AI, Bonnefond A, Carstensen L; Bone Mineral Density in Childhood Study (BMDCS); Early Genetics and Lifecourse Epidemiology (EAGLE) consortium, Eriksson J, Flexeder C, Franke L, Geller F, Geserick M, Hartikainen AL, Haworth CM, Hirschhorn JN, Hofman A, Holm JC, Horikoshi M, Hottenga JJ, Huang J, Kadarmideen HN, Kähönen M, Kiess W, Lakka HM, Lakka TA, Lewin AM, Liang L, Lyytikäinen LP, Ma B, Magnus P, McCormack SE, McMahon G, Mentch FD, Middeldorp CM, Murray CS, Pahkala K, Pers TH, Pfäffle R, Postma DS, Power C, Simpson A, Sengpiel V, Tiesler CM, Torrent M, Uitterlinden AG, van Meurs JB, Vinding R, Waage J, Wardle J, Zeggini E, Zemel BS, Dedoussis GV, Pedersen O, Froguel P, Sunyer J, Plomin R, Jacobsson B, Hansen T, Gonzalez JR, Custovic A, Raitakari OT, Pennell CE, Widén E, Boomsma DI, Koppelman GH, Sebert S, Järvelin MR, Hyppönen E, McCarthy MI, Lindi V, Harri N, Körner A, Bønnelykke K, Heinrich J, Melbye M, Rivadeneira F, Hakonarson H, Ring SM, Smith GD, Sørensen TI, Timpson NJ, Grant SF, Jaddoe VW; Early Growth Genetics (EGG) Consortium; Bone Mineral Density in Childhood Study BMDCS.

Hum Mol Genet. 2015 Nov 24. pii: ddv472. [Epub ahead of print]