Longitudinal Pubertal Height Growth Summary Data (2024)

Here we modeled longitudinal height growth with Super-Imposition by Translation And Rotation (SITAR) growth curve analysis on ~56,000 trans-ancestry samples with repeated height measurements from age 5 years to adulthood. We performed genetic analysis on six phenotypes representing the magnitude, timing, and intensity of the pubertal growth spurt. To investigate the lifelong impact of genetic variants associated with pubertal growth trajectories, we performed genetic correlation analyses and phenome-wide association studies in the Penn Medicine BioBank and the UK Biobank.

We identified 26 genome-wide significant loci and leveraged trans-ancestry data to perform fine-mapping. Our data reveals genetic relationships between pediatric height growth and health across the life course, with different growth trajectories correlated with different outcomes.

Dataset Details

We have six sets of summary result files, each relating to a different phenotype. All results are from trans-ancestry GWAS. Each analysis was run separately in females and males, and combined. The six phenotypes were as follows.

1. The take-off phase of the pubertal growth spurt (height at age 10 in girls and 12 in boys)

   PG_I_TRANS_female.result.filtered.txt.gz

   PG_I_TRANS_male.result.filtered.txt.gz

   PG_I_TRANS.result.filtered.txt.gz

2. total pubertal growth, between ages 8 and adult

   PG_II_TRANS_female.result.filtered.txt.gz

   PG_II_TRANS_male.result.filtered.txt.gz

   PG_II_TRANS.result.filtered.txt.gz

3. late pubertal growth, between ages 14 and adult

   PG_III_TRANS_female.result.filtered.txt.gz

   PG_III_TRANS_male.result.filtered.txt.gz

   PG_III_TRANS.result.filtered.txt.gz

Three phenotypes derived from SITAR longitudinal modelling:

4. a-size

   PG_IV_TRANS_female.result.filtered.txt.gz

   PG_IV_TRANS_male.result.filtered.txt.gz

   PG_IV_TRANS.result.filtered.txt.gz

5. b-timing

   PG_V_TRANS_female.result.filtered.txt.gz

   PG_V_TRANS_male.result.filtered.txt.gz

   PG_V_TRANS.result.filtered.txt.gz

6. c-intensity

   PG_VI_TRANS_female.result.filtered.txt.gz

   PG_VI_TRANS_male.result.filtered.txt.gz

   PG_VI_TRANS.result.filtered.txt.gz

Acknowledging The Data

When using data from the downloadable meta-analyses results, please acknowledge the source of the data as follows:

Data on pubertal growth have been contributed by the EGG Consortium and have been downloaded from www.egg-consortium.org.

In addition to the above acknowledgement, please cite the paper below: