Early Growth Genetics Consortium

Gestational Duration Summary Data (2023)

We are releasing the summary data from our maternal genome-wide meta-analyses of gestational duration, preterm and post-term deliveries combining data from the EGG consortium and other large cohorts. Data were imputed up to the reference panels from the 1000 Genomes Project (Phase 1 v3) or HRC reference panel or a combination of these with cohort-specific whole genome sequences. Gestational duration was assessed in days, only for spontaneous deliveries. Preterm delivery was defined as a spontaneous delivery <259 days (37 completed gestational weeks) or by using the ICD-10 O60 code, and controls as a delivery occurring between 273 and 294 days (39 and 42 gestational weeks). Post-term delivery was defined as a delivery occurring >294 days (42 completed weeks) or ICD-10 O48 code, and controls as a spontaneous delivery between 273 and 294 days (39 and 42 gestational weeks).

Summary files provide information on chromosome, genomic position (NCBI build 37), rsID, effect allele, other allele, effect allele frequency, beta, standard error, p-value, sample size, heterogeneity score, and heterogeneity p-value at approximately 9 million variants passing quality control.

Dataset Details

- EGG_Maternal_GWAMA_allPTD.txt.gz. Maternal GWAS meta-analysis of preterm delivery in 233,290 women (n cases = 15,419). Data from 23andMe is not included in the meta-analysis.

- EGG_Maternal_GWAMA_GAraw.txt.gz. Maternal GWAS meta-analysis of gestational duration (days) in 151,987 women. Data from 23andMe is not included in the meta-analysis.

- EGG_Maternal_GWAMA_postTerm.txt.gz. Maternal GWAS meta-analysis of post-term delivery in 131,279 women (n cases = 15,972). Data from 23andMe has not been part of the meta-analysis.

Acknowledging The Data

When using data from the downloadable meta-analyses results please acknowledge the source of the data as follows:

Data on birth weight has been contributed by the EGG Consortium and has been downloaded from www.egg-consortium.org

In addition to the above acknowledgement, please cite the paper below:

Genetic effects on the timing of parturition and links to fetal birth weight.

Sole-Navais P, Flatley C, Steinthorsdottir V, Vaudel M, Juodakis J, Chen J, Laisk T, ... Jacobsson B

Nature Genetics 2023 doi:10.1038/s41588-023-01343-9