Early Growth Genetics Consortium

Birth Weight Summary Data (2013)

We are releasing the summary data from our genome-wide meta-analyses of birth weight, in order to enable other researchers to examine particular variants or loci of their interest for association with this trait. The file includes P-values and direction of effect at over 2 million directly genotyped or imputed single nucleotide polymorphisms (SNPs) from the HapMap project (release 27). To minimise the possibility of identification of individuals from these summary results, we are not releasing allele frequency data from our samples. Trait values for birth weight (BW) were transformed to a Z-score and assessed for association with each SNP using linear regression of the birth weight Z-score against genotype using an additive genetic model, with sex and, where available, gestational age as covariables.

Dataset Details

The birth weight dataset was generated by performing a meta-analysis of up to 18 population-based European studies (total n = 26,836 individuals). The data as a gzipped text file can be downloaded here: EGG_BW2_DISCOVERY.txt.gz.

Acknowledging The Data

When using data from the downloadable meta-analyses results please acknowledge the source of the data as follows:

Data on birth weight trait has been contributed by EGG Consortium and has been downloaded from www.egg-consortium.org.

In addition to the above acknowledgement, please cite the paper below:

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Horikoshi M, Yaghootkar H, Mook-Kanamori DO et al.

Nat Genet. 2013 Jan;45(1):76-82