Early Growth Genetics Consortium

Childhood Obesity Summary Data

We are releasing the summary data from the genome-wide meta-analysis of childhood obesity (cases defined as BMI>95th percentile; controls defined as BMI<50th percentile) in subjects of European ancestry, in order to enable other researchers to examine particular variants or loci of their interest for association with this trait. The file includes P-values and direction of effect at over 2 million directly genotyped or imputed single nucleotide polymorphisms (SNPs) based on the HapMap Utah residents of Northern and Western European ancestry (CEU) SNPs (Phase 2, release 22). To minimize the possibility of identification of individuals from these summary results, we are not releasing allele frequency data from our samples. We assessed for association with each SNP in the case-control setting using an additive genetic model.

Dataset Details

The childhood obesity dataset was generated by performing a meta-analysis of up to 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI). The data made available is where the genomic control was applied to the overall meta-analysis results and the results filtered to where there was data available for at least 8 participating cohorts for any given SNP. The data as a gzipped text file can be downloaded here: EGG_Obesity_Meta_Analysis_1.txt.gz.

Acknowledging The Data

When using data from the downloadable meta-analyses results please acknowledge the source of the data as follows:

Data on the childhood obesity trait has been contributed by EGG Consortium and has been downloaded from www.egg-consortium.org.

In addition to the above acknowledgement, please cite the paper below:

A genome-wide association meta-analysis identifies new childhood obesity loci.

J.P. Bradfield, H.R. Taal, et al.

Nat Genet. 2012 May;44(5):526-31